環境醫學研究中心專題演講

From Dose-response Relationship of Environmental Epidemiological Study Outcomes to Derivation of Tolerable Daily Intake of Exposure

演講者:陳主智研究員/國家衛生研究院群體健康研究所

演講摘要Talk Abstract:

  Epidemiological study outcomes provides the most direct evidence of environmental toxicant effects on human body, rather than experimental animal studies. However, up to date, almost all the current regulatory level of tolerable daily intake (TDI) (or reference dose, RfD) was established based on toxicological data, with the exception of methylmercury. One main difficulty might be exposure uncertainties as well as lack of suitable large-scale observational studies. In this talk, I will briefly explain the derivation of benchmark dose (BMD) for the RfD of methylmercury by US EPA IRIS in 1995 based on Faroe Islands data. I will then demonstrate the BMD we derived for melamine based on 13 nephrolithiasis cases from 932 children who enrolled in three Department of Health hospitals in Taiwan during the melamine outbreak in 2008. Finally, for the phthalate incident in 2011, we derived the corresponding BMD for di-2-ethylhexyl phthalate (DEHP) for pregnant women based on 122 mother-child pairs for the association between prenatal DEHP exposure and behavioral problems in children.

演講資訊:

(一)演講時間:107年8月13日禮拜一中午12:00-13:00

(二)演講地點:高雄醫學大學勵學大樓二樓第一會議室

(三)演講主題:從環境流行病學研究的劑量反應關係到每日耐受暴露量的推導

(四)報名網址(請點)

歡迎各位對議題有興趣者，當日自備午餐一同參與

主辦單位:高雄醫學大學環境醫學研究中心

協辦單位:高教深耕計畫

活動聯繫人:陳奕璇

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